Immunosuppression and Cardiac Allograft Vasculopathy: A Multivariate Odds Ratio Analysis
نویسندگان
چکیده
منابع مشابه
Cardiac allograft vasculopathy: a review.
Cardiac allograft vasculopathy (CAV) is a major factor limiting long-term survival after cardiac transplantation. CAV is an accelerated form of coronary artery disease (CAD) that is characterized by concentric fibrous intimal hyperplasia along the length of coronary vessels. Both immunologic and nonimmunologic risk factors contribute to the development of CAV by causing endothelial dysfunction ...
متن کاملCardiac allograft vasculopathy: recent developments.
Cardiac allograft vasculopathy (CAV) continues to limit the long-term success of cardiac transplantation. Recent insights have underscored the fact that innate and adaptive immune responses are involved in the pathogenesis of CAV. Vascular lesions are the result of cumulative endothelial injuries induced both by alloimmune responses and by nonspecific insults (including ischemia-reperfusion inj...
متن کاملCardiac Allograft Vasculopathy: Past, Present and Future!
Cardiac Allograft Vasculopathy (CAV) is a serious complication after heart transplantation in adults as well as children and once developed irreversibly compromises the outcome of the recipients. Human leukocyte antigen mismatches, number and duration of rejection episodes, type of immunosuppression and presence of antibody -mediated rejection are among the most relevant immunological risk fact...
متن کاملCardiac allograft vasculopathy: diagnosis, therapy, and prognosis
Development of cardiac allograft vasculopathy represents the major determinant of long-term survival in patients after heart transplantation. Due to graft denervation, these patients seldom present with classic symptoms of angina pectoris, and the first clinical presentations are progressive heart failure or sudden cardiac death. Although coronary angiography remains the routine technique for c...
متن کاملConversion to sirolimus as primary immunosuppression attenuates the progression of allograft vasculopathy after cardiac transplantation.
BACKGROUND We investigated the potential of conversion to sirolimus (SRL) as a primary immunosuppressant in attenuating cardiac allograft vasculopathy progression. METHODS AND RESULTS Twenty-nine cardiac transplant recipients were converted to SRL 3.8+/-3.4 years after transplantation with complete calcineurin inhibitor (CNI) withdrawal. Secondary immunosuppressants (azathioprine or mycopheno...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Heart and Lung Transplantation
سال: 2016
ISSN: 1053-2498
DOI: 10.1016/j.healun.2016.01.561